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Related Experiment Videos

High compared with standard dose lipase pancreatic supplement.

P J Robinson1, A Olinsky, A L Smith

  • 1Professorial Department of Thoracic Medicine, Royal Children's Hospital, Melbourne, Australia.

Archives of Disease in Childhood
|January 1, 1989
PubMed
Summary

A new pancreatic enzyme supplement, Cotazym-S-Forte, offers equivalent fat absorption to Pancrease but requires half the dosage. This finding supports its potential as an effective pancreatic insufficiency treatment.

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Area of Science:

  • Gastroenterology
  • Pharmacology
  • Digestive Health

Background:

  • Pancreatic insufficiency requires enzyme replacement therapy.
  • Standard pancreatin supplements vary in lipase activity.
  • Optimizing dosage and efficacy of pancreatic enzymes is crucial.

Purpose of the Study:

  • To compare the efficacy of Cotazym-S-Forte with a standard pancreatin supplement.
  • To evaluate fat absorption in patients receiving different pancreatic enzyme dosages.

Main Methods:

  • A randomized crossover trial was conducted.
  • Cotazym-S-Forte (10,000 BP lipase units/capsule) was compared to Pancrease (5,000 BP lipase units/capsule).
  • Dosage was adjusted to achieve equivalent lipase activity.

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Main Results:

  • Cotazym-S-Forte at half the usual dose achieved equivalent fat absorption compared to Pancrease.
  • The study demonstrated comparable efficacy between the two pancreatic supplements.

Conclusions:

  • Cotazym-S-Forte provides a potentially more convenient and effective option for pancreatic enzyme replacement therapy.
  • Lower capsule count with maintained efficacy may improve patient compliance.