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Persistent Albuminuria in Children with Type 2 Diabetes: A Canadian Paediatric Surveillance Program Study

Elizabeth A C Sellers1, Stasia Hadjiyannakis2, Shazhan Amed3

  • 1Department of Pediatrics and Child Health, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

The Journal of Pediatrics
|October 17, 2015
PubMed

Insights

Persistent albuminuria affects 5.1% of Canadian children with type 2 diabetes, often within the first year of diagnosis. It is linked to First Nations heritage and maternal diabetes exposure.

Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Public Health

Background:

  • Type 2 diabetes in children is increasing.
  • Albuminuria is an early marker of diabetic kidney disease.
  • Understanding early kidney complications in pediatric type 2 diabetes is crucial.

Purpose of the Study:

  • To determine the prevalence of persistent albuminuria in Canadian children (<18 years) with type 2 diabetes.
  • To identify clinical features associated with persistent albuminuria in this population.

Main Methods:

  • A national prospective surveillance study conducted from 2010-2012.
  • Involved a network of pediatricians and pediatric endocrinologists reporting cases.
  • Persistent albuminuria defined by elevated albumin-to-creatinine ratio in ≥2 of 3 samples over 3-6 months.

Main Results:

  • Estimated prevalence of persistent albuminuria was 5.1%.
  • Median diabetes duration at diagnosis was 21 days.
  • Associated factors included female sex (64%), First Nations heritage (80%), maternal diabetes exposure (65%), and family history of renal disease (48%).

Conclusions:

  • Persistent albuminuria is prevalent in Canadian youth with type 2 diabetes, occurring early post-diagnosis.
  • Significant regional variation and associations with First Nations heritage and maternal diabetes exposure were observed.
  • Highlights the need for early screening and targeted interventions.
Abstract

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