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Updated: Mar 31, 2026

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction
Published on: July 18, 2025
Pathological Features of the Unilateral Favorable Histology Nephroblastoma with Relapse
Hiroaki Fukuzawa1, Takeshi Aoba2, Makiko Yoshida3
1a Department of Pediatric Surgery , Kobe Children's Hospital , Kobe , Japan.
Purpose:
To evaluate the pathological features of the primary lesion in patients with relapse of unilateral favorable histology nephroblastoma.
Material And Methods:
Fifty-eight patients with unilateral favorable histology nephroblastoma who underwent initial nephrectomy before chemotherapy were categorized into one of two groups: the nonrelapsed group (n = 52) and the relapsed group (n = 6). The histological subtypes of both groups and pathological features of the relapsed group were re-evaluated retrospectively.
Results:
The histological subtypes of all relapsed cases were classified as blastemal predominant. In three of six cases with relapse, sheets of spindle-shaped blastemal cells that were histologically reminiscent of synovial sarcoma were predominant (massive sarcomatoid pattern).
Conclusions:
The histological blastemal predominant subtype of nephroblastoma is a strong indicator of relapse. In particular, the blastemal predominant subtype with massive sarcomatoid pattern may have a higher risk of relapse.
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