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Advantage and limitations of nitrofurantoin in multi-drug resistant Indian scenario

Laishram Shakti, Balaji Veeraraghavan1

  • 1Department of Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.

Indian Journal of Medical Microbiology
|October 17, 2015
PubMed

Insights

Antibiotic resistance is a growing concern. Nitrofurantoin effectively treats urinary tract infections (UTIs) caused by various bacteria, including multi-drug resistant strains, making it a crucial option for UTIs.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Microbiology

Background:

  • Antibiotic-resistant pathogens pose significant mortality and morbidity risks.
  • Nitrofurantoin is a broad-spectrum bactericidal antibiotic with established efficacy in treating urinary tract infections (UTIs).

Purpose of the Study:

  • To highlight the role of nitrofurantoin in treating UTIs.
  • To emphasize nitrofurantoin's effectiveness against multi-drug resistant pathogens.

Main Methods:

  • The study reviews the mechanism of action of nitrofurantoin.
  • It examines its application in treating acute lower urinary tract infections.

Main Results:

  • Nitrofurantoin exhibits bactericidal activity against Gram-positive and Gram-negative pathogens like E. coli, Klebsiella sp., Enterobacter sp., Enterococcus sp., and Staphylococcus aureus.
  • It functions by interfering with bacterial cell wall synthesis, protein synthesis, and DNA replication.

Conclusions:

  • Nitrofurantoin is a valuable therapeutic agent for acute lower UTIs.
  • Its efficacy against multi-drug resistant organisms makes it a preferred choice in the face of rising antibiotic resistance.

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