Related Experiment Video
Updated: Mar 31, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
HIV reverse transcriptase gene mutations in anti-retroviral treatment naïve rural people living with HIV/AIDS
K Mohanakrishnan1, A Kasthuri, S K Amsavathani
1Department of Microbiology, Sri Muthukumaran Medical College and Research Institute, Mangadu, Chennai, Tamil Nadu, India.
Abstract:
This study is designed to find out the mutational variations of reverse transcriptase (RT) gene of HIV, after the traditional drug usage among anti-retroviral therapy naïve rural people living with HIV/AIDS. HIV Reactive patients, who were exposed for indigenous medicines such as Siddha, Ayurveda etc., for a minimum period of 6 months were taken for this study. Among 40 patients, two samples (5.55%) demonstrated high-level mutational resistance variations for nucleoside RT inhibitor (NRTI) and non-NRTI. The predominant polymorphisms detected were K122E (91.7%), V60I (91.7%), V35T (89%), Q207E (89%), D177E (89%), T200A (86.1%), S48T (83.33%), K173A (80.6%).
Related Concept Videos
Retrovirus Life Cycles
Viral Mutations
Size and Structure of Viral Genomes
Retroviruses
Viruses with RNA Genomes
Mechanisms of Retrovirus-induced Cancers

