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Rare yeasts causing fungemia in immunocompromised and haematology patients: Case series from Delhi
M R Capoor1, D K Gupta, P K Verma
1Department of Microbiology, Vardhman Mahaveer Medical College and Safdarjung Hospital, New Delhi, India.
Abstract:
Systemic fungal infection related to fluconazole-resistant yeasts are emerging in immunocompromised patients. In this case-series, we report eight cases of fungemia caused by Trichosporon spp. (2), Stephanoascus ceferrii (1), Kodamaea ohmeri (1), Pichia kutrawersi (2), Candida rugosa (1) and Candida lusitianae (1) in immunocompromised patients. All the yeasts except (Trichosporon asahii) were sequenced. As these rare species are inherently resistant to antifungal agents and they may lead to the development of nosocomial outbreaks, therefore, accurate identification followed by antifungal susceptibility testing is crucial for proper treatment and management.
Insights
Emerging fluconazole-resistant yeasts cause systemic fungal infections in immunocompromised patients. Accurate identification and antifungal susceptibility testing are crucial for managing these rare, potentially nosocomial infections.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Clinical Microbiology
Background:
- Systemic fungal infections pose a significant threat to immunocompromised individuals.
- Emergence of fluconazole-resistant yeasts necessitates investigation into alternative pathogens.
- Nosocomial outbreaks due to rare fungal species are a growing concern.
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