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Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

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The InflammTORy Powers of Senescence

Manuel Serrano1

  • 1Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

Trends in Cell Biology
|October 17, 2015
PubMed

Insights

Cellular senescence triggers inflammation via secreted factors. The mechanistic target of rapamycin (mTOR) pathway is key to this secretory phenotype, suggesting mTOR inhibitors could combat senescence-associated inflammation and aging.

Area of Science:

  • Cellular biology
  • Aging research
  • Inflammation

Background:

  • Cellular senescence, a state of irreversible growth arrest, is linked to inflammation through secreted factors.
  • The mechanistic target of rapamycin (mTOR) pathway's role in senescence is an emerging area of research.

Purpose of the Study:

  • To investigate the role of mTOR in the secretory phenotype of senescent cells.
  • To explore the therapeutic potential of targeting mTOR in senescence-related pathologies.

Main Methods:

  • Analysis of cellular senescence markers.
  • Investigation of cytokine secretion profiles.
  • Pharmacological inhibition of the mTOR pathway.

Main Results:

  • mTOR was identified as a critical regulator of the senescence-associated secretory phenotype (SASP).
  • Inhibition of mTOR reduced the secretion of pro-inflammatory cytokines by senescent cells.

Conclusions:

  • mTOR is a key driver of the pathological inflammation associated with cellular senescence.
  • Targeting mTOR with inhibitors presents a potential therapeutic strategy for age-related diseases and may explain rapamycin's anti-aging effects.
Keywords:
agingcancercytokinesinflammationmTORsenescence

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