Related Experiment Video

Updated: Mar 31, 2026

Nanoparticle-mediated siRNA Gene-silencing in Adult Zebrafish Heart
09:12

Nanoparticle-mediated siRNA Gene-silencing in Adult Zebrafish Heart

Published on: July 29, 2018

8.7K

Nanocarriers Assisted siRNA Gene Therapy for the Management of Cardiovascular Disorders

Rahul Maheshwari, Muktika Tekade, Piyoosh A Sharma

  • 1School of Pharmacy, Department of Pharmaceutical Technology, International Medical University, JalanJalil Perkasa 19, 57000 Kuala Lumpur, Malaysia. rakeshtekade@gmail.com.

Current Pharmaceutical Design
|October 17, 2015
PubMed

Insights

Small interfering RNA (siRNA) offers a novel gene silencing approach for cardiovascular diseases (CVDs). This strategy targets overexpressed genes, providing a promising new avenue for managing conditions like heart failure and atherosclerosis.

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular diseases (CVDs) are a leading global cause of mortality.
  • Traditional treatments for CVDs are complemented by emerging innovative strategies.
  • Gene silencing using small interfering RNA (siRNA) is a rapidly developing therapeutic area for CVDs.

Purpose of the Study:

  • To review the application of siRNA in managing cardiovascular diseases.
  • To highlight specific gene targets for siRNA-based therapies.
  • To discuss various delivery systems for siRNA in CVD treatment.

Main Methods:

  • Review of current literature on siRNA applications in cardiovascular medicine.
  • Analysis of siRNA's gene silencing mechanism.
  • Examination of different siRNA delivery vehicles.

Main Results:

  • siRNA effectively silences overexpressed pathological genes in CVDs.
  • siRNA offers a versatile approach to down-regulate disease-associated genes, proteins, or receptors.
  • Various delivery systems, including hydrogels, polyplexes, peptides, liposomes, and dendrimers, are being explored for siRNA application.

Conclusions:

  • siRNA represents a promising therapeutic strategy for cardiovascular diseases.
  • Targeted gene silencing via siRNA can address the molecular underpinnings of CVDs.
  • Advancements in delivery systems are crucial for the clinical translation of siRNA therapies for CVDs.

More Related Videos

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model06:03

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model

Published on: June 11, 2020

9.9K
In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

8.0K

Related Concept Videos

siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
19.0K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
28.1K
Gene Therapy00:59

Gene Therapy

4.8K
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
8.3K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.4K