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MDM4 SNP34091 (rs4245739) and its effect on breast-, colon-, lung-, and prostate cancer risk

Liv B Gansmo1,2, Pål Romundstad3, Einar Birkeland1,2

  • 1Section of Oncology, Department of Clinical Science, University of Bergen, Bergen, Norway.

Cancer Medicine
|October 17, 2015
PubMed

Insights

The MDM4 gene variant (SNP34091) may reduce breast cancer risk, particularly when combined with a specific MDM2 gene variant (SNP309GG). This genetic interaction was not linked to lung, colon, or prostate cancer risk.

Area of Science:

  • Genetics and Oncology
  • Cancer Risk Factors
  • Molecular Biology

Background:

  • MDM4 protein regulates tumor suppressor p53 via MDM2 interaction.
  • MDM4 amplification is observed in various cancers.
  • A specific MDM4 polymorphism (SNP34091) may affect mRNA levels via microRNA binding.

Purpose of the Study:

  • To investigate the association between MDM4 SNP34091 and cancer risk.
  • To examine the combined effect of MDM4 SNP34091 and MDM2 SNP309 on cancer risk.
  • To assess risk for breast, colon, lung, and prostate cancers in a Norwegian population.

Main Methods:

  • Population-based case-control study.
  • Genotyping of MDM4 SNP34091 and MDM2 SNP309 in 7,079 cancer patients and 3,747 controls.
  • Statistical analysis of genetic associations and interactions.

Main Results:

  • MDM4 SNP34091 was not associated with risk for colon, lung, or prostate cancer.
  • A marginally significant reduced risk for breast cancer was observed with MDM4 SNP34091C in a recessive model.
  • A significantly reduced risk for breast cancer was found for MDM4 SNP34091CC in individuals with the MDM2 SNP309GG genotype.

Conclusions:

  • MDM4 SNP34091 status is associated with a reduced risk of breast cancer, especially in conjunction with the MDM2 SNP309GG genotype.
  • No association was found between MDM4 SNP34091 and the risk of lung, colon, or prostate cancer.
  • The findings suggest a potential gene-gene interaction influencing breast cancer susceptibility.
Keywords:
Cancer riskMDM4SNP309SNP34091population based

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