Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

19.3K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
19.3K
Karyotyping01:17

Karyotyping

70.1K
Overview
70.1K
Karyotyping01:17

Karyotyping

12.0K
12.0K
Genome Copying Errors02:46

Genome Copying Errors

5.5K
DNA replication is a well-evolved process that copies millions of base pairs with high fidelity during each cell division. Occasionally a wrong base or a long stretch of wrong bases may get added to the daughter strands. If the errors are left unchecked, cells might accumulate several mutations that might endanger their  survival. Therefore, the copying errors are checked and repaired at three levels.
5.5K
Gene Duplication and Divergence02:37

Gene Duplication and Divergence

8.2K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
8.2K
Genetic Variation01:25

Genetic Variation

1.6K
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modulating Fermi-level pinning and carrier injection efficiency in 2D β-TeO₂/metal van der Waals heterostructure via interlayer distance.

Journal of physics. Condensed matter : an Institute of Physics journal·2026
Same author

Targeting of Gpx8-CSF1 axis resets the immune milieu of lung tumor and overcomes resistance to anti-PD-1 therapy.

Cell death and differentiation·2026
Same author

Corrigendum to 'The catalytic triad of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation' [Cellular Signalling 26 (2014) 2266-2275].

Cellular signalling·2026
Same author

JOSD1-mediated stabilization of SUFU controls pancreatic cancer progression.

Cell death & disease·2026
Same author

Efficacy of a high-protein food for special medical purposes in midlife and older adults at risk of malnutrition: a multicenter, randomized, active-controlled clinical study.

The journal of nutrition, health & aging·2026
Same author

Histone Modification Complex JMJ704-HDA709 Negatively Regulates Salinity Tolerance in Rice.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Related Experiment Video

Updated: Mar 31, 2026

Detection of Copy Number Alterations Using Single Cell Sequencing
09:45

Detection of Copy Number Alterations Using Single Cell Sequencing

Published on: February 17, 2017

12.3K

cnvCurator: an interactive visualization and editing tool for somatic copy number variations.

Lingnan Ma1,2,3, Maochun Qin4, Biao Liu5

  • 1Department of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY, 14263, USA. lm69@buffalo.edu.

BMC Bioinformatics
|October 17, 2015
PubMed
Summary

cnvCurator is a new tool that helps researchers accurately identify copy number variations (CNVs) in tumor genomes. This software facilitates the manual review of CNV calling results for improved cancer research.

More Related Videos

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
11:02

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing

Published on: October 18, 2013

20.0K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.6K

Related Experiment Videos

Last Updated: Mar 31, 2026

Detection of Copy Number Alterations Using Single Cell Sequencing
09:45

Detection of Copy Number Alterations Using Single Cell Sequencing

Published on: February 17, 2017

12.3K
Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
11:02

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing

Published on: October 18, 2013

20.0K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.6K

Area of Science:

  • Genomics
  • Cancer Research
  • Bioinformatics

Background:

  • Somatic copy number variations (CNVs) are significant genomic alterations in tumors, often containing oncotargets.
  • Accurate detection of CNVs is crucial for cancer genome analysis but is frequently limited.
  • Manual review and refinement of CNV segments are often necessary to enhance accuracy.

Purpose of the Study:

  • To introduce cnvCurator, a software tool designed for interactive visualization and editing of somatic CNV calling results.
  • To provide researchers with a specialized utility for curating CNV data.

Main Methods:

  • Development of a user-friendly interface for visualizing and editing CNV data.
  • Implementation of segment-centric indexing and display of CNV calling results.
  • Integration of multiple CNV-specific information for concurrent, interactive examination.

Main Results:

  • cnvCurator offers dedicated functions for interactively visualizing and editing somatic CNV calls.
  • The tool presents CNV results with a segment-centric approach, unlike general genomics viewers.
  • It includes features for examining and curating CNV calls using multiple data types.

Conclusions:

  • cnvCurator provides essential utilities for the manual review and editing of somatic CNV caller outputs.
  • The curated CNV segments generated by cnvCurator can be reliably used in downstream applications.
  • This tool enhances the accuracy and utility of CNV analysis in cancer research.