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Related Experiment Video

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Breed-specific reference intervals for assessing thyroid function in seven dog breeds.

Rebecca L Hegstad-Davies1, Sheila M F Torres2, Leslie C Sharkey2

  • 1Departments of Veterinary Population Medicine (Hegstad-Davies, Gresch, Davies), College of Veterinary Medicine, University of Minnesota, St. Paul, MinnesotaClinical Sciences (Torres, Sharkey), College of Veterinary Medicine, University of Minnesota, St. Paul, MinnesotaDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN (Muñoz-Zanzi) rdavies@umn.edu.

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
|October 17, 2015
PubMed
Summary
This summary is machine-generated.

Breed-specific reference intervals for thyroid hormones are necessary in dogs. This study found significant variations in thyroxine (T4), free T4 (FT4), and thyrotropin (TSH) levels across seven dog breeds, supporting tailored diagnostic ranges.

Keywords:
Breed specificcaninehealthyreference intervalsthyroid function

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Area of Science:

  • Comparative endocrinology
  • Canine clinical pathology
  • Veterinary diagnostics

Background:

  • Thyroid hormone levels (T4, FT4, TSH) are crucial for canine health assessment.
  • Existing reference intervals (RIs) are often non-breed-specific, potentially leading to misinterpretation.
  • Significant physiological variations in thyroid hormone concentrations can exist among different dog breeds.

Purpose of the Study:

  • To determine if breed-specific reference intervals (RIs) for thyroxine (T4), free T4 (FT4), and thyrotropin (TSH) are warranted in specific dog breeds.
  • To establish comprehensive RIs for T4, FT4, and TSH in Alaskan Malamutes, Collies, English Setters, Golden Retrievers, Keeshonds, Samoyeds, and Siberian Huskies.
  • To investigate the influence of breed, sex, and age on thyroid hormone concentrations in healthy dogs.

Main Methods:

  • Serum samples were collected from 693 healthy dogs across seven distinct breeds.
  • Thyroxine (T4), free T4 (FT4), and thyrotropin (TSH) concentrations were measured using validated assays.
  • Data underwent rigorous veterinary review, and reference intervals were calculated using robust and nonparametric methods.

Main Results:

  • Significant variations in mean T4, FT4, and TSH concentrations were observed among the studied breeds.
  • Many dogs exhibited T4 and FT4 levels at or below established non-breed-specific lower limits.
  • Factors such as female sex, increasing age were associated with altered thyroid hormone levels.

Conclusions:

  • The substantial inter-breed variability in thyroid hormone levels strongly supports the need for breed-specific reference intervals.
  • Implementing breed-specific RIs will enhance the accuracy of thyroid function assessment in these canine populations.
  • Careful consideration of pre-analytical and analytical factors is essential for reliable thyroid testing in dogs.