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Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems.

Feng Jiang1,2, Biao Liu3,4, Jun Lu5,6

  • 1Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. jiangfenghz@163.com.

International Journal of Molecular Sciences
|October 17, 2015
PubMed
Summary
This summary is machine-generated.

Aptamers, or DNA/RNA ligands, offer high selectivity for molecular recognition. This review explores their use in targeted drug delivery systems, covering aptamer selection, advantages, and future perspectives.

Keywords:
SELEXaptameraptamer-functionalized targeted drug delivery systemsaptamer-nanomaterial conjugated systemsaptamer-small molecule conjugated systems

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Drug Delivery Systems

Background:

  • Aptamers are nucleic acid or peptide molecules selected via SELEX for high affinity and specificity.
  • They are increasingly recognized for their potential in targeted drug delivery applications.
  • Existing aptamer-based delivery systems are broadly categorized into small molecule conjugates and nanomaterial conjugates.

Purpose of the Study:

  • To review recent advancements in aptamer selection techniques.
  • To summarize the application of aptamers in two main categories of targeted drug delivery systems.
  • To discuss the benefits, limitations, and future outlook of aptamer-mediated drug delivery.

Main Methods:

  • Systematic Evolution of Ligands by Exponential Enrichment (SELEX) for aptamer screening.
  • Review of literature on aptamer-small molecule conjugated systems.
  • Review of literature on aptamer-nanomaterial conjugated systems.

Main Results:

  • Aptamers demonstrate superior molecular recognition capabilities compared to traditional ligands.
  • Both aptamer-small molecule and aptamer-nanomaterial conjugates show promise for targeted delivery.
  • Recent progress highlights advancements in aptamer selection and their integration into delivery platforms.

Conclusions:

  • Aptamers are highly effective ligands for targeted drug delivery.
  • Aptamer-functionalized systems offer unique advantages but also present challenges.
  • Further research into aptamer selection and delivery system design is crucial for clinical translation.