Computer-assisted predictive mathematical relationship among plasma acetaminophen concentration and time and...

A microcomputer program in BASIC for predicting hepatoxicity in man resulting from a single overdosage ingestion of acetaminophen was designed. A formula used in this program is derived from the data reported by Prescott and his coworkers (Lancet i (1971) 519-522). Analysis of the actually reported and the computer-assisted predicted data has shown that the computer-assisted predictive formula may be clinically helpful in determining if the plasma acetaminophen level is in the toxic or nontoxic range.