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Related Experiment Videos

Nocardia asteroides keratitis presenting as a persistent epithelial defect.

H D Perry1, J S Nauheim, E D Donnenfeld

  • 1Division of Ophthalmology, Nassau County Medical Center, East Meadow.

Cornea
|January 1, 1989
PubMed
Summary

A persistent epithelial defect in an elderly male was successfully treated with trimethoprim-sulfamethoxazole. This topical antibiotic resolved the Nocardia asteroides infection within 48 hours.

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Area of Science:

  • Ophthalmology
  • Medical Microbiology

Background:

  • Persistent epithelial defects can be challenging to treat, often resisting conventional therapies.
  • Ocular infections require accurate etiological diagnosis for effective management.

Observation:

  • An elderly male patient presented with a chronic epithelial defect unresponsive to multiple treatments.
  • Gram stain and culture revealed Nocardia asteroides as the causative agent.

Findings:

  • Topical trimethoprim-sulfamethoxazole was administered for the Nocardia asteroides keratitis.
  • The persistent epithelial defect resolved rapidly within 48 hours of treatment initiation.

Implications:

  • Trimethoprim-sulfamethoxazole is an effective topical treatment for Nocardia asteroides keratitis.

Related Experiment Videos

  • Prompt microbiological diagnosis is crucial for resolving complex ocular surface diseases.
  • This case highlights a successful therapeutic approach for resistant microbial keratitis.