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Pseudomonas cepacia keratitis.

J H Levy1, H R Katz

  • 1Sinai Hospital of Baltimore, Department of Ophthalmology, Maryland 21215.

Cornea
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Pseudomonas cepacia causes serious eye infections, particularly in immunocompromised individuals using contact lenses after surgery. This bacterium is resistant to standard treatments, necessitating increased awareness and diagnostic consideration.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Pseudomonas cepacia is an emerging opportunistic pathogen causing severe nosocomial infections.
  • This bacterium exhibits resistance to common antipseudomonal antibiotics.
  • P. cepacia has been linked to endophthalmitis and conjunctivitis, but not previously keratitis.

Observation:

  • A case of Pseudomonas cepacia keratitis is reported in a patient using topical steroids and contact lenses post-penetrating keratoplasty.
  • An experimental rabbit model of P. cepacia keratitis was successfully developed to study the infection.

Findings:

  • This study details the first reported case of P. cepacia keratitis.
  • The experimental model validates P. cepacia as a causative agent of infectious keratitis.

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Implications:

  • P. cepacia should be considered in the differential diagnosis of infectious keratitis, especially in immunocompromised patients and those with a history of contact lens wear or ocular surgery.
  • Increased clinical vigilance is required for this resistant pathogen in hospital-acquired infections affecting the cornea.