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IL-22/STAT3-Induced Increases in SLURP1 Expression within Psoriatic Lesions Exerts Antimicrobial Effects against

Yasuhiro Moriwaki1, Kiyoko Takada1, Toshinori Nagasaki1

  • 1Department of Pharmacology, Faculty of Pharmacy, Keio University, Minato-ku, Tokyo 105-8512, Japan.

Plos One
|October 17, 2015
PubMed
Abstract

Insights

Secretin, like peptide-1 (SLURP1) is implicated in psoriasis pathophysiology. It regulates keratinocyte proliferation and differentiation, and inhibits Staphylococcus aureus growth, suggesting a role in managing this skin condition.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Immunology

Background:

  • Secretin, like peptide-1 (SLURP1) is the gene responsible for Mal de Meleda (MDM), a skin disorder.
  • SLURP1 is a key factor in keratinocyte proliferation and differentiation.
  • The role of SLURP1 in psoriasis and its regulatory mechanisms in keratinocytes are not well understood.

Purpose of the Study:

  • To investigate the involvement of SLURP1 in the pathophysiology of psoriasis.
  • To utilize an imiquimod (IMQ)-induced psoriasis mouse model and normal human epidermal keratinocytes (NHEKs) for this study.

Main Methods:

  • Assessed SLURP1 expression in IMQ-induced psoriasis model mice skin.
  • Stimulated NHEKs with inflammatory cytokines (IL-17, IL-22, TNF-α) to analyze SLURP1 mRNA expression.
  • Investigated the role of STAT3 signaling pathway in IL-22-induced SLURP1 expression.
  • Evaluated the antibacterial activity of SLURP1 against Staphylococcus aureus (S. aureus).

Main Results:

  • SLURP1 expression was elevated in the skin of IMQ-induced psoriasis model mice.
  • IL-22 significantly upregulated SLURP1 mRNA expression in NHEKs, an effect dependent on STAT3 signaling.
  • SLURP1 demonstrated significant inhibition of S. aureus growth.

Conclusions:

  • SLURP1 plays a role in psoriasis pathophysiology.
  • SLURP1 influences keratinocyte proliferation and differentiation.
  • SLURP1 exhibits antimicrobial properties against S. aureus, potentially impacting psoriasis severity.

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