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Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

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Asthma: Pathogenesis and Management

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Related Experiment Video

Updated: Mar 31, 2026

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10

Published on: November 19, 2016

Air pollution and allergic diseases.

Eric B Brandt¹, Jocelyn M Biagini Myers, Patrick H Ryan

¹aDivision of Asthma Research bDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Current Opinion in Pediatrics

|October 17, 2015

Summary

Traffic-related air pollutants (TRAPs) significantly impact asthma development and exacerbation, especially in children. New research offers innovative methods to assess exposure and identify at-risk individuals for targeted interventions.

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Last Updated: Mar 31, 2026

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Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

Area of Science:

Environmental Health
Pulmonology
Epidemiology

Background:

Traffic-related air pollutants (TRAPs) are increasingly recognized for their role in asthma development, persistence, and exacerbation.
High TRAP exposure is prevalent in urban areas, affecting large populations, including children attending schools near high-traffic zones.

Purpose of the Study:

To review recent epidemiologic and mechanistic studies on the impact of traffic pollution on allergic diseases.
To highlight innovative methods for assessing and quantifying traffic pollution exposure.
To identify vulnerable populations and individuals affected by TRAP exposure.

Main Methods:

Review of recent epidemiologic and mechanistic studies.
Analysis of novel methods for traffic pollution assessment and quantification.
Identification of biological mechanisms underlying TRAP effects.

Main Results:

New insights into the impact of traffic pollution on allergic diseases and their underlying biology.
Development of innovative methods for exposure assessment and identification of at-risk individuals.
Understanding of specific biological pathways affected by TRAP exposure.

Conclusions:

Recent findings provide a substantial impact on clinical practice and research.
Novel methods for exposure quantification and at-risk individual identification are emerging.
Mechanistic studies are identifying new targets for intervention in individuals most affected by TRAP exposure.