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Pulmonary papillary adenoma presenting in central portion: a case report
Xu-Yong Lin1,2, Qiang Han3,4, En-Hua Wang5,6
1Department of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, 110001, China. linxuyong@hotmail.com.
Diagnostic Pathology
|October 18, 2015
Summary
Pulmonary papillary adenoma, a rare lung tumor, can occur centrally. This case highlights a central pulmonary papillary adenoma in a young female, expanding diagnostic considerations.
Area of Science:
- Pulmonology
- Oncology
- Pathology
Background:
- Pulmonary papillary adenoma is an uncommon lung neoplasm.
- These tumors typically manifest in the peripheral lung regions.
Observation:
- A case study of a 17-year-old Chinese female with a central lung mass.
- Imaging revealed an incidentally detected, well-defined mass in the right pulmonary hilar region.
- Histological examination showed predominant papillary structures with epithelial cells resembling type II pneumocytes.
Findings:
- Immunohistochemical analysis confirmed diffuse positivity for cytokeratin, cytokeratin 7, TTF-1, EMA, surfactant apoprotein A, Napsin A, P63, and β-catenin.
- The Ki-67 proliferation index was low, approximately 2%.
- Morphological and immunohistochemical features were consistent with pulmonary papillary adenoma.
Implications:
- This case expands the known clinical presentation of pulmonary papillary adenoma.
- It suggests that pulmonary papillary adenoma should be considered in the differential diagnosis of central lung masses.
- Highlights the importance of comprehensive histopathological and immunohistochemical evaluation for accurate diagnosis.
