[Gene transfer in laboratory animals]

Describing purpose and method of genetransfer by pronuclear microinjection comprehensively application on laboratory animals are reviewed. Experiments on the production of rabbits and mice transgenic for several uteroglobin-hybrid-genes (B2B3UG CAT; H/B/72/CAT; UG TAg; UG 11.8) were performed and resulted in four rabbit fetuses and one stillborne rabbit transgenic for UG TAg and one mouse transgenic for UG 11.8. These experiments are part of investigations on uteroglobin as a model of geneexpression regulated by steroid hormones.