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Evidence for neuropathic processes in chronic cough
1Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Pulmonary Pharmacology & Therapeutics
|October 18, 2015
Summary
Chronic cough may be a neuropathic condition due to sensory nerve damage. Treatments for neuropathic pain show promise for managing this difficult-to-treat cough.
Area of Science:
- Neurology
- Pulmonology
- Pharmacology
Background:
- Chronic cough is a prevalent symptom with challenging management.
- Existing cough suppressants (antitussives) offer limited efficacy and side effects.
- Patients often report sensory symptoms and hypersensitivity to stimuli, suggesting neural dysfunction.
Purpose of the Study:
- To explore the concept of 'cough hypersensitivity syndrome'.
- To investigate chronic cough as a neuropathic condition.
- To evaluate the potential of neuropathic pain treatments for chronic cough.
Main Methods:
- Review of current understanding of chronic cough mechanisms.
- Analysis of patient-reported sensory symptoms.
- Examination of treatment outcomes with neuropathic pain medications.
Main Results:
- Chronic cough is increasingly viewed as a neuropathic condition.
- Sensory nerve dysfunction in the upper airway and larynx is implicated.
- Agents like gabapentin and amitriptyline show potential in managing chronic cough.
Conclusions:
- Chronic cough may stem from sensory nerve damage.
- The 'cough hypersensitivity syndrome' concept aligns with neuropathic mechanisms.
- Further research into neuropathic cough could yield more effective antitussives.
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