Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in c-onc expression during embryonal carcinoma cell differentiation.

T Sejersen1, P Jin, M Rahm

  • 1Department of Medical Cell Genetics, Karolinska Institutet, Stockholm, Sweden.

Environmental Health Perspectives
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Clinicopathologic features and prognosis of retroperitoneal unicentric Castleman disease: report of 38 patients].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2026
Same author

Filamin C Modulates Cellular Mechanoresponse Through Focal Adhesion Turnover and Actin Stabilization.

Cytoskeleton (Hoboken, N.J.)·2026
Same author

[Reasonable extent of No.12a lymph node dissection in laparoscopic surgery for locally advanced distal gastric cancer].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2026
Same author

Integrated omics-based analysis reveals distinct microbial-metabolite interaction networks in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps in a Chinese population.

Rhinology·2026
Same author

Integrated omics-based analysis reveals distinct microbial-metabolite interaction networks in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps in a Chinese population.

Rhinology·2026
Same author

[Patterns of lymph node metastasis and prognosis in locally-advanced gastric cancer after neoadjuvant immunotherapy combined with chemotherapy].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2025

Protooncogene expression changes during embryonal carcinoma cell differentiation. Some oncogenes are crucial for differentiation, while others may be secondary events without functional significance.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cancer Research

Background:

  • Embryonal carcinoma (EC) cells share characteristics with pluripotent stem cells.
  • Protooncogenes play critical roles in cellular growth and differentiation.
  • Understanding oncogene expression in EC cells offers insights into early development and cancer.

Purpose of the Study:

  • To investigate the expression patterns of various protooncogenes and oncogenes in murine EC cells.
  • To analyze changes in oncogene expression during EC cell differentiation.
  • To explore the potential functional significance of these expression changes in differentiation.

Main Methods:

  • Analysis of protooncogene and oncogene expression in EC cells and their differentiated progeny.

Related Experiment Videos

  • Induction of differentiation in EC cells and monitoring of gene expression profiles.
  • Comparison of expression levels of specific oncogenes (e.g., c-myc, N-myc, c-mos, int-2, EGF receptor).

    • Main Results:

    • Ubiquitous protooncogenes (c-myc, c-K-ras, c-abl) and restricted c-onc genes (N-myc, c-mos, int-2) are expressed in EC cells.
    • EC cell differentiation is associated with altered expression of specific protooncogenes/oncogenes.
    • Increased expression observed for c-src, c-fos, int-1, int-2, and EGF receptor; decreased expression for c-mos, c-K-ras, c-myc, N-myc, and platelet-derived growth factor.

    Conclusions:

    • Protooncogene and oncogene expression profiles differ between EC cells and their differentiated derivatives.
    • The functional role of observed expression changes in EC cell differentiation remains to be elucidated.
    • These alterations may be integral to the differentiation process or merely secondary, non-functional events.