Related Experiment Video
Updated: Mar 31, 2026
05:27
An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
Published on: June 30, 2021
5.2K
The Iron age of host-microbe interactions
Miguel P Soares1, Günter Weiss2
1Instituto Gulbenkian de Ciência, Oeiras, Portugal mpsoares@igc.gulbenkian.pt guenter.weiss@i-med.ac.at.
EMBO Reports
|October 18, 2015
Summary
Host adaptive responses regulating iron metabolism influence resistance and disease tolerance to microbial infections. Understanding these mechanisms is crucial for managing infectious diseases and maintaining health.
Area of Science:
- Microbiology
- Immunology
- Host-Pathogen Interactions
Background:
- Microbes significantly impact human health, causing disease by disrupting homeostasis.
- Host defense strategies involve resistance (harming microbes) and disease tolerance (maintaining homeostasis).
- The integration of these distinct host defense strategies remains incompletely understood.
Purpose of the Study:
- To explore how host adaptive responses in iron (Fe) metabolism affect resistance and disease tolerance to infection.
- To elucidate the general principles governing the interplay between iron metabolism and host defense.
Main Methods:
- The study explores general principles of host adaptive responses.
- Focuses on the role of iron (Fe) metabolism in infection outcomes.
- Integrates concepts of resistance and disease tolerance mechanisms.
Main Results:
- Host adaptive responses regulating iron metabolism are key determinants of infection outcomes.
- Iron metabolism influences both the host's ability to resist infection and tolerate disease.
- These responses are functionally integrated, impacting overall host defense.
Conclusions:
- Host iron metabolism plays a critical role in modulating resistance and disease tolerance to microbial infections.
- Understanding these adaptive responses offers insights into managing infectious diseases.
- Further research into the integration mechanisms is warranted.
Keywords:
anemia of chronic diseasedisease tolerancehemeironmacrophagenutritional immunitytissue damage controlMore Related Videos
06:43Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways
Published on: January 13, 2016
9.5K
09:49Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
Published on: November 18, 2022
2.9K
Related Concept Videos
01:28History of Microbiology
16.1K
Microbiology, a scientific field dedicated to the study of microorganisms, has undergone profound development since its inception in the 17th century. Its history is marked by key discoveries and technological advancements that have shaped our understanding of life at the microscopic level and transformed medicine, agriculture, and industry.Early Foundations of MicrobiologyThe early foundations of microbiology were built on groundbreaking observations and the development of pioneering...
16.1K
01:22Microbial Interactions: Parasitism
52
Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
52
01:25Colonisation of Pathogens
35
Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...
35
01:22Introduction to the Human Microbiota
68
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
68
01:26Factors Affecting the Risk of Infection
14.6K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.6K
01:27The Oral Microbiota
38
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
38