Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

13.9K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
13.9K
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

9.5K
9.5K
Bone Remodeling01:40

Bone Remodeling

41.1K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
41.1K
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

4.8K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Infection Rate by Gustilo-Anderson Classification in Open Tibial Shaft Fractures Treated with an Intramedullary Nail - A Meta-Analysis.

Journal of orthopaedic trauma·2026
Same author

Editorial Commentary: Too Many Questions Remain to Consider Slope-Correcting Osteotomy for Most Primary Anterior Cruciate Ligament Reconstructions.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association·2026
Same author

Anesthesia clinicians' perspectives on peripheral nerve blocks for hip fractures in older adults.

BMC anesthesiology·2026
Same author

Long-Term Outcomes Associated With Peripheral Nerve Blocks for Hip Fracture Surgery: A Retrospective Comparison of Medicare Data.

Journal of the American Geriatrics Society·2026
Same author

The Impact of Geographical Background on the Orthopedic Surgery Residency Match.

Journal of surgical education·2025
Same author

Influence of Training Load on the Risk of Injuries in Preprofessional Contemporary Dancers: A Scoping Review.

Orthopaedic journal of sports medicine·2025

Related Experiment Video

Updated: Mar 31, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

18.0K

Osteochondral allograft.

Arissa M Torrie1, William W Kesler1, Joshua Elkin1

  • 1Department of Orthopaedics, Bone and Joint Institute, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, 30 Hope Drive, Hershey, PA, 17033, USA.

Current Reviews in Musculoskeletal Medicine
|October 18, 2015
PubMed
Summary
This summary is machine-generated.

Osteochondral allograft transplantation is increasingly popular, with improved techniques enhancing graft availability and chondrocyte viability. Despite potential reoperations, patient satisfaction remains high, especially for unipolar lesions.

Keywords:
Articular cartilage restorationOsteochondral allograft

More Related Videos

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.7K
Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

11.0K

Related Experiment Videos

Last Updated: Mar 31, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

18.0K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.7K
Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

11.0K

Area of Science:

  • Orthopedic surgery
  • Regenerative medicine
  • Biomaterials science

Background:

  • Osteochondral allograft transplantation has gained significant traction over the last decade.
  • Advancements in graft storage have improved chondrocyte viability and extended graft availability.
  • Outcomes are increasingly stratified by defect location and etiology.

Purpose of the Study:

  • To review the current status and outcomes of osteochondral allograft transplantation.
  • To highlight the impact of improved storage techniques on graft availability and viability.
  • To analyze patient satisfaction and survival rates based on defect characteristics.

Main Methods:

  • Literature review of recent studies on osteochondral allograft transplantation.
  • Analysis of outcomes stratified by lesion location and etiology.
  • Evaluation of graft survival rates and reoperation frequencies.
  • Assessment of patient-reported satisfaction.

Main Results:

  • Unipolar osteochondral lesions demonstrate favorable outcomes with high 10-year survival rates.
  • Osteochondral allograft transplantation shows promising long-term survival.
  • Patients frequently require reoperation, yet report high satisfaction levels.

Conclusions:

  • Osteochondral allograft transplantation is a viable option for chondral defects, with improving outcomes.
  • Enhanced storage techniques support increased graft availability and viability.
  • High patient satisfaction persists despite the need for potential reoperations.