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[Serotonin effect on gastric secretion induced by various stimuli]
Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova
|January 1, 1989
Summary
Serotonin injection in dogs inhibited gastric secretion and insulin release. It also reduced stomach mucosal blood flow and increased gastrointestinal motility, with effects modulated by vagotomy and benzohexonium.
Area of Science:
- Gastroenterology
- Neuroendocrinology
- Pharmacology
Background:
- Serotonin plays a role in regulating gastrointestinal functions.
- Understanding serotonin's impact on gastric secretion and motility is crucial for digestive health research.
Purpose of the Study:
- To investigate the effects of serotonin on gastric secretion, insulin release, mucosal blood flow, and gastrointestinal motility in dogs.
- To explore the influence of vagotomy and benzohexonium on serotonin's physiological effects.
Main Methods:
- Subcutaneous and intravenous administration of serotonin (0.3 mg/kg) in dogs.
- Assessment of gastric secretion and insulin levels.
- Measurement of stomach mucosal blood flow and gastrointestinal motility.
- Evaluation of serotonin's effects following vagotomy and benzohexonium administration.
Main Results:
- Subcutaneous serotonin inhibited carbacholine-induced gastric secretion.
- Intravenous serotonin suppressed insulin secretion.
- Serotonin decreased stomach mucosal blood flow and increased gastrointestinal motility in both hungry and replete dogs.
- Vagotomy and benzohexonium attenuated the inhibitory effects of serotonin on secretion induced by peripheral stimuli.
Conclusions:
- Serotonin exerts significant inhibitory effects on gastric secretion and insulin release in dogs.
- Serotonin influences gastric mucosal blood flow and gastrointestinal motility.
- The vagus nerve and ganglionic blockade modulate serotonin's actions on the digestive system.