Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

7.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
7.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thermoelectric signature of quantum critical phase in a doped spin-liquid candidate.

Nature communications·2023
Same author

Low dose antibiotic ingestion potentiates systemic and microbiome changes induced by silver nanoparticles.

NanoImpact·2022
Same author

Gastrointestinal: Superior mesenteric vein aneurysm treated using interventional radiology.

Journal of gastroenterology and hepatology·2022
Same author

Phase Diagram for Light-Induced Superconductivity in κ-(ET)_{2}-X.

Physical review letters·2021
Same author

Terahertz-field-induced polar charge order in electronic-type dielectrics.

Nature communications·2021
Same author

Electronic and spin structures of CaMn<sub>4</sub>O<sub></sub> clusters in the S<sub>0</sub> state of the oxygen evolving complex of photosystem II. Domain-based local pair natural orbital (DLPNO) coupled-cluster (CC) calculations using optimized geometries and natural orbitals (UNO) by hybrid density functional theory (HDFT) calculations.

Physical chemistry chemical physics : PCCP·2020

Related Experiment Video

Updated: Mar 31, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

8.7K

Alendronate does not prevent long bone fragility in an inactive rat model.

K Naruse1, K Uchida1, M Suto1,2

  • 1Department of Orthopedic Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, 252-0374, Japan.

Journal of Bone and Mineral Metabolism
|October 18, 2015
PubMed
Summary

Alendronate (ALN) did not prevent bone fragility caused by inactivity in aged female rats. Bisphosphonates may be more effective for individuals with limited daily activity.

Keywords:
BisphosphonateInactiveMechanical loadingOsteoporosisWalking

More Related Videos

Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats
05:43

Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats

Published on: August 31, 2022

3.6K
Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model
08:53

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

Published on: January 1, 2017

9.9K

Related Experiment Videos

Last Updated: Mar 31, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

8.7K
Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats
05:43

Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats

Published on: August 31, 2022

3.6K
Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model
08:53

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

Published on: January 1, 2017

9.9K

Area of Science:

  • Gerontology
  • Orthopedics
  • Pharmacology

Background:

  • Osteoporosis pathogenesis in elderly women involves estrogen deficiency and inactivity.
  • Rodent models are needed to study bisphosphonate efficacy against these factors separately.
  • Alendronate (ALN) is a common bisphosphonate used to treat osteoporosis.

Purpose of the Study:

  • To compare the efficacy of alendronate (ALN) on aged female rats that were sedentary, estrogen-deficient, or both.
  • To investigate the effects of inactivity and estrogen deficiency on bone health.
  • To evaluate ALN's effectiveness in mitigating bone deterioration under different conditions.

Main Methods:

  • Aged female rats underwent ovariectomy or sham surgery, followed by an 8-week experimental period.
  • Rats were either sedentary (sitting position) or active (walking in cages), with or without ALN administration.
  • Bone parameters were assessed using mechanical testing, CT scans, microspectroscopy, and histomorphometry.

Main Results:

  • ALN was ineffective against reduced breaking stress caused by inactivity, despite increased bone mineral density in sedentary ALN-treated groups.
  • Inactivity led to decreased bone toughness, altered geometry (larger marrow space), and signs of aged bone (increased mineral-to-matrix and carbonate-to-phosphate ratios).
  • Sitting caused deficits in cortical bone quality and geometry, resulting in fragility, even with ALN treatment.

Conclusions:

  • Alendronate (ALN) does not prevent bone fragility induced by inactivity in aged female rats.
  • Inactivity significantly impairs bone quality and geometry, leading to fragility.
  • Bisphosphonate therapy may be most suitable for osteoporotic individuals who are not limited by daily activity.