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Related Experiment Video

Updated: Mar 31, 2026

Transpupillary Two-Photon In Vivo Imaging of the Mouse Retina

Transpupillary Two-Photon In Vivo Imaging of the Mouse Retina

Published on: February 13, 2021

A model microfluidics-based system for the human and mouse retina.

Shawn Mishra¹, Ankush Thakur¹, Stephen Redenti²

¹Department of Biomedical Engineering, City College of New York, New York, NY, USA.

Biomedical Microdevices

|October 18, 2015

Summary

Researchers developed the μRetina, a microfluidics device, to study retinal cell migration for treating degenerative retinal diseases. This technology aids in understanding cell movement to improve transplantation therapies and develop new treatments.

Keywords:

Diffusion Migration Progenitor Retina SDF-1

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Last Updated: Mar 31, 2026

Transpupillary Two-Photon In Vivo Imaging of the Mouse Retina

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Area of Science:

Biomedical Engineering
Ophthalmology
Cell Biology

Background:

Degenerative retinal diseases cause vision loss, and current transplantation therapies are limited by low cell motility post-transplantation.
Understanding retinal cell migration is crucial for developing effective vision restoration treatments.

Purpose of the Study:

To develop and validate a novel microfluidics device, the μRetina, for studying retinal lineage cell migration.
To investigate the migratory behavior of retinal progenitor cells in response to chemical gradients within biomimetic retinal geometries.

Main Methods:

Utilized soft lithography to create the μRetina microfluidics device.
Employed coupled computer simulations and experimental validations to confirm chemical gradient formation.
Captured real-time images of cell migration within the device in response to stromal-derived factor (SDF-1).

Main Results:

Successfully characterized and confirmed chemical concentration gradients within the μRetina device.
Observed and quantified radial and theta cell migration in response to SDF-1 gradients.
Demonstrated the device's capability to examine concentration-dependent cell migration.

Conclusions:

The μRetina device is a valuable tool for studying retinal cell migration dynamics.
Findings can inform strategies to enhance current retinal transplantation therapies.
The technology supports the development of novel, migration-targeted treatments for retinal diseases.