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Evolution of Hematopoietic Cell Transplantation for Immunoglobulin Light Chain Amyloidosis

Taimur Sher1, Angela Dispenzieri1, Morie A Gertz1

  • 1Department of Medicine, Mayo Clinic, Jacksonville, Florida.

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
|October 18, 2015
PubMed

Immunoglobulin light chain amyloidosis is the most common type of systemic amyloidosis. Hematopoietic stem cell transplantation (HCT) is an effective treatment option for AL however due to multi-organ involvement in this disease HCT is feasible in a minority of patients. To maximize the benefit and minimize toxicity it is of paramount importance to optimize the selection of patients for HCT. In this review we discuss evolution of HCT and its typical application to a case of AL amyloidosis.

Keywords:
AL amyloidosisHematopoeitic stem cell transplantationImmunoglobulin light chain amyloidosisStem cell transplantation

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