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Can Free Water Transport Be Used as a Clinical Parameter for Peritoneal Fibrosis in Long-Term PD Patients?
Raymond T Krediet1, Deirisa Lopes Barreto2, Dirk G Struijk3
1Division of Nephrology, Department of Medicine, Academic Medical Center, University of Amsterdam, The Netherlands r.t.krediet@amc.uva.nl.
Abstract:
Sodium sieving in peritoneal dialysis (PD) occurs in a situation with high osmotically-driven ultrafiltration rates. This dilutional phenomenon is caused by free water transport through the water channel aquaporin-1. It has recently been described that encapsulating peritoneal fibrosis is associated with impaired free water transport, despite normal expression of aquaporin-1. In this review, it will be argued that free water transport can be used for assessment of fibrotic peritoneal alterations, due to the water-binding capacity of collagen. Finally, the consequences for clinical practice will be discussed.
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