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Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

4.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

2.0K
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
2.0K
Heart Valves01:16

Heart Valves

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The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
14.1K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

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Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
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Related Experiment Video

Updated: Mar 31, 2026

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
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Giving your heart to pathology.

Jim Klaassen

    The Veterinary Record
    |October 18, 2015
    PubMed
    Summary

    Dr. Jim Klaassen, a clinical pathologist, brings extensive experience in veterinary diagnostics and research to Axiom Veterinary Laboratories. His background includes small animal practice and leadership roles in commercial veterinary labs.

    Area of Science:

    • Veterinary Pathology
    • Animal Health Diagnostics

    Background:

    • Dr. Jim Klaassen has a comprehensive background in veterinary medicine.
    • His experience spans small animal practice, academic lecturing, and preclinical research.
    • He has held significant leadership positions in commercial veterinary diagnostic laboratories within the USA.

    Purpose of the Study:

    • To announce the appointment of Dr. Jim Klaassen as a clinical pathologist at Axiom Veterinary Laboratories.
    • To highlight Dr. Klaassen's expertise and contributions to the field of veterinary pathology.

    Main Methods:

    • Not applicable for this announcement.

    Main Results:

    • Not applicable for this announcement.

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    Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
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    Conclusions:

    • Dr. Klaassen's expertise will enhance Axiom Veterinary Laboratories' capabilities.
    • His appointment signifies a valuable addition to the clinical pathology team.