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Updated: Mar 31, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
Atrioventricular septal defect: From embryonic development to long-term follow-up
Emmeline E Calkoen1, Mark G Hazekamp2, Nico A Blom3
1Departments of Paediatric Cardiology and Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands.
Abstract:
Atrioventricular septal defect (AVSD) covers a spectrum of heart anomalies with a common atrioventricular connection and has an incidence of 4-5.3 per 10.000 live births. About half of the AVSDs occur in patient with Down syndrome. This review provides a bench to bedside overview of AVSD. Developmental aspects, nomenclature, anatomy, and classification of AVSD are discussed. Furthermore an overview of genetic and maternal risk factors for AVSD is provided, and available literature on (fetal) diagnosis, surgical techniques and follow-up is presented. Special attention is given to differences in developmental, anatomical and prognostic factors of AVSD between non-syndromic and Down syndrome patients.
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