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Related Experiment Videos

[Borna disease].

A Mayr1

  • 1Institut für Medizinische Mikrobiologie, Tierärztliche Fakultät, Universität München.

Immunitat Und Infektion
|February 1, 1989
PubMed
Summary
This summary is machine-generated.

Borna disease virus infections offer insights into persistent central nervous system infections, including slow virus diseases. Research highlights commonalities with unexplained chronic neurological conditions in humans and animals.

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Area of Science:

  • Neurovirology
  • Immunology
  • Pathogenesis

Context:

  • Borna disease serves as a model for persistent central nervous system (CNS) viral infections.
  • Chronic progressive neurological diseases in animals and humans often remain unexplained.
  • Latent and active Borna disease forms share characteristics with these enigmatic conditions.

Purpose:

  • To describe the consequences of persistent Borna disease virus infections in the CNS.
  • To highlight the similarities between Borna disease and unexplained chronic neurological disorders.
  • To outline available laboratory methods for studying the disease's pathogenesis and immunology.

Summary:

  • Persistent Borna disease virus infections of the CNS, particularly slow virus diseases, are examined.

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  • The study notes shared features between Borna disease (latent and active forms) and unexplained chronic progressive CNS diseases in animals and humans.
  • Simple virological and serological laboratory procedures, along with appropriate animal models and cell cultures, are available for investigation.

    • Impact:

    • Provides a framework for understanding complex CNS infections.
    • Suggests Borna disease as a relevant model for studying chronic neurological conditions.
    • Facilitates further research into the pathogenesis and immunology of slow virus diseases affecting the nervous system.