Related Experiment Videos
Flipping a Lipid-Linked Oligosaccharide? You Must Whip It!
1Department Pharmacology, UT-Southwestern Medical Center at Dallas, Dallas, TX, USA.
Trends in Biochemical Sciences
|October 19, 2015
Abstract:
The mechanism for flipping large lipid-linked oligosaccharides across membranes has remained a paradox. Perez et al. now report the structure of the PglK protein of C. jejuni, a flippase for a bacterial lipid-linked oligosaccharide, and reveal an unexpected whip-like mechanism.