Related Experiment Video
Updated: Mar 31, 2026
Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
Published on: April 5, 2024
Evidence of a genetic link between endometriosis and ovarian cancer
Alice W Lee1, Claire Templeman2, Douglas A Stram1
1Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Objective:
To evaluate whether endometriosis-associated genetic variation affects risk of ovarian cancer.
Design:
Pooled genetic analysis.
Setting:
University hospital.
Patient(S):
Genetic data from 46,176 participants (15,361 ovarian cancer cases and 30,815 controls) from 41 ovarian cancer studies.
Intervention(S):
None.
Main Outcome Measure(S):
Endometriosis-associated genetic variation and ovarian cancer.
Result(S):
There was significant evidence of an association between endometriosis-related genetic variation and ovarian cancer risk, especially for the high-grade serous and clear cell histotypes. Overall we observed 15 significant burden statistics, which was three times more than expected.
Conclusion(S):
By focusing on candidate regions from a phenotype associated with ovarian cancer, we have shown a clear genetic link between endometriosis and ovarian cancer that warrants further follow-up. The functional significance of the identified regions and SNPs is presently uncertain, though future fine mapping and histotype-specific functional analyses may shed light on the etiologies of both gynecologic conditions.
