Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

8.1K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.1K
The Tumor Microenvironment02:17

The Tumor Microenvironment

3.1K
3.1K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.3K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.3K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

8.3K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
8.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An LSCC-specific R-loop-related model predicts prognosis and neoadjuvant immunotherapy response and identifies EIF5A2-mediated tumor-immune crosstalk.

World journal of surgical oncology·2026
Same author

PGT-Net: A Physics-Guided Transformer-CNN Hybrid Network for Low-Light Image Enhancement and Object Detection in Traffic Scenes.

Journal of imaging·2026
Same author

Diagnostic CT-guided online adaptive radiotherapy for locally advanced colon cancer: a prospective implementation and feasibility study.

Clinical and translational radiation oncology·2026
Same author

Multidimensional information detection of liver cancer cell exosomes treated with shikonin.

Analytical methods : advancing methods and applications·2026
Same author

Molecular Dynamics Study on the Adsorption of Antimicrobial Peptides on the Surface of Al<sub>2</sub>O<sub>3</sub> Nanostructures in a Water Environment.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

The impact of data consistency on deep learning models for nasopharyngeal cancer organ auto-segmentation.

Biomedical physics & engineering express·2026
Same journal

Corrigendum to "Elevated MMP10/13 mediated barrier disruption and NF-κB activation aggravate colitis and colon tumorigenesis in both individual or full miR-148/152 family knockout mice" [Cancer Lett. (2022) 31 529 53-69].

Cancer letters·2026
Same journal

Corrigendum to "PI3K PROTAC overcomes the lapatinib resistance in PIK3CA-mutant HER2 positive breast cancer" [Cancer Lett. 598 (2024) 217112].

Cancer letters·2026
Same journal

Differential bioenergetic reprogramming driven by sorafenib reveals therapeutic vulnerabilities in biliary tract cancers.

Cancer letters·2026
Same journal

Transcriptomic-based molecular classification of ampullary adenocarcinoma.

Cancer letters·2026
Same journal

Corrigendum to "LRH1 promotes pancreatic cancer metastasis" [Cancer Lett. (2014) 24 350 (1-2) 15-24].

Cancer letters·2026
Same journal

Corrigendum to "Histone deacetylase inhibitors upregulate Snail via Smad2/3phosphorylation and stabilization of Snail to promote metastasis of hepatoma cells" [Cancer Lett. 420 (2018) 1-13].

Cancer letters·2026
See all related articles

Related Experiment Video

Updated: Mar 31, 2026

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

10.5K

Immunotherapy and tumor microenvironment.

Haidong Tang1, Jian Qiao1, Yang-Xin Fu1

  • 1Department of Pathology and Committee on Immunology, University of Chicago, Chicago, IL 60637, USA.

Cancer Letters
|October 20, 2015
PubMed
Summary
This summary is machine-generated.

Cancer immunotherapy offers durable responses but benefits few patients. Understanding the tumor microenvironment (TME) interactions is key to improving immunotherapy efficacy for more advanced cancer patients.

Keywords:
CAR T-cell therapyCheckpoint blockadeChemokineCytokineTumor microenvironmentTumor-infiltrating immune cells

More Related Videos

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:04

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

1.9K
Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors
06:32

Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors

Published on: August 18, 2023

3.3K

Related Experiment Videos

Last Updated: Mar 31, 2026

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

10.5K
Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:04

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

1.9K
Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors
06:32

Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors

Published on: August 18, 2023

3.3K

Area of Science:

  • Oncology
  • Immunology

Background:

  • Cancer immunotherapy has revolutionized treatment, yielding durable responses in advanced cancers.
  • However, current immunotherapies benefit only a subset of patients, necessitating further research.

Purpose of the Study:

  • To review the influence of the tumor microenvironment (TME) on cancer immunotherapy efficacy.
  • To explore strategies for manipulating the TME to enhance immunotherapy outcomes.

Main Methods:

  • Literature review of recent research on immunotherapy and the tumor microenvironment.
  • Analysis of studies investigating the interplay between tumor cells, immunomodulators, and immune responses within the TME.

Main Results:

  • The TME dynamically modulates immune responses, impacting immunotherapy effectiveness.
  • Specific interactions within the TME can either inhibit or promote anti-tumor immunity.

Conclusions:

  • Understanding TME-immunotherapy interactions is crucial for deciphering mechanisms of action.
  • Targeting the TME presents a promising avenue for improving current immunotherapy regimens and expanding patient benefits.