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Updated: Mar 31, 2026
09:14
Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
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Epstein-Barr virus-associated inflammatory pseudotumor presenting as a colonic mass
Shunyou Gong1, Iwona Auer2, Rajan Duggal3
1Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Human Pathology
|October 20, 2015
Summary
This study details a rare Epstein-Barr virus (EBV)-positive inflammatory pseudotumor (IPT) found in the ascending colon, a location seldom affected by this condition. Recognizing this unique gastrointestinal manifestation is crucial for accurate diagnosis and patient care.
Area of Science:
- Gastroenterology
- Pathology
- Oncology
Background:
- Epstein-Barr virus (EBV)-positive inflammatory pseudotumor (IPT) typically affects the spleen and liver.
- Gastrointestinal (GI) tract involvement by EBV-positive IPT is exceptionally rare.
- Spindle cell morphology in IPT can mimic other neoplastic and reactive conditions.
Observation:
- A case of EBV-positive IPT originating in the ascending colon is presented.
- The lesion exhibited spindle cells positive for smooth muscle actin but negative for follicular dendritic cell markers.
- An abundant lymphoid infiltrate with reactive follicles, plasma cells, and lymphocytes was noted.
Findings:
- The colonic lesion was characterized by EBV-positive spindle cells with myofibroblastic features.
- Differential diagnostic considerations included ALK-positive inflammatory myofibroblastic tumor, IgG4-related disease, and peripheral T-cell lymphoma.
- This represents the first reported case of EBV-positive IPT in the GI tract in Western literature.
Implications:
- Accurate diagnosis of GI EBV-positive IPT is essential to avoid misdiagnosis.
- Increased awareness of this rare entity can improve patient management strategies.
- Further research may elucidate the specific pathogenesis and clinical behavior of GI IPT.
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