Related Experiment Video For Caco-2 cells
Updated: Mar 31, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Effect of β-cyclodextrin on the internalization of nanoparticles into intestine epithelial cells
Lorena García-González1, Lilián Yépez-Mulía2, Adriana Ganem1
1División de Estudios de Posgrado (Tecnología Farmacéutica), Universidad Nacional Autónoma de México, Mexico.
Abstract:
The influence of β-cyclodextrin on the interaction and internalization of PLGA nanoparticles into intestine epithelial cells was assessed. For this purpose β-cyclodextrin was adsorbed on PLGA nanoparticles. Interaction of nanoparticles with Caco-2 cells, determined by fluorescence, was expressed as the number of particles per cell. Confocal microscopy confirmed the localization of the particles in the cell monolayer. The results showed that adsorption of β-cyclodextrin on the surface of PLGA nanoparticles reduces interaction with mucin, enhancing in this way the internalization into the Caco-2 cells.
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