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To be visualized by an electron microscope, either transmission or scanning, biological samples need to be fixed (stabilized) so the electron beam does not destroy them and dried thoroughly (desiccated/dehydrated) so the vacuum does not affect them. Fixation needs to be done as quickly as possible because the sample properties will start changing as soon as it is removed from its natural environment. For example, in a tissue sample, the oxygen levels begin decreasing, causing an altered...
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Applying a novel electrostatic dry powder coating technology to pellets.

Qingliang Yang1, Yingliang Ma1, Jesse Zhu1

  • 1Particle Technology Research Centre, Department of Chemical and Biochemical Engineering, University of Western Ontario, London, Ontario N6A 5B9, Canada.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|October 20, 2015
PubMed
Summary

A novel electrostatic dry powder coating technology successfully created piroxicam pellets with immediate, sustained, and delayed release profiles. This cost-effective method offers excellent stability and pharmaceutical coating potential.

Keywords:
Coating panDry powder coatingElectrostatic coatingPelletsPlasticizer

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Traditional pharmaceutical coating methods often involve organic solvents or aqueous suspensions, posing environmental and cost challenges.
  • Achieving specific drug release profiles (immediate, sustained, delayed) requires precise control over coating formulations and processes.

Purpose of the Study:

  • To develop and evaluate a novel electrostatic dry powder coating technology for pharmaceutical pellets.
  • To investigate the use of different coating materials for controlled drug release.
  • To assess the efficiency, stability, and cost-effectiveness of the dry powder coating method.

Main Methods:

  • Coating piroxicam pellets using Eudragit® EPO, Eudragit® RS/RL, and Acryl EZE as dry powders via electrostatic deposition.
  • Utilizing a three-step process: preheating, powder adhesion, and curing, with liquid plasticizers to modify powder properties.
  • Employing Scanning Electron Microscopy (SEM) to analyze coating film formation and dissolution tests to evaluate drug release profiles.

Main Results:

  • SEM analysis confirmed that increased curing temperature or time improved coating film formation.
  • Dissolution tests successfully demonstrated immediate, sustained, and delayed release profiles based on coating formulations.
  • Dry powder coated pellets showed excellent stability after 1 month at 40 °C/75% RH.

Conclusions:

  • The novel electrostatic dry powder coating technology effectively produces pharmaceutical pellets with tailored drug release characteristics.
  • This method significantly reduces coating time and cost compared to conventional solvent-based and aqueous coating techniques.
  • The developed dry powder coating technology presents a promising and viable alternative for the pharmaceutical industry.