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Related Concept Videos

Production of Organic Acids01:25

Production of Organic Acids

64
Lactic acid, an important organic acid extensively applied in food, pharmaceutical, and biodegradable polymer industries, is primarily produced via microbial fermentation. This method is favored over chemical synthesis due to its environmental sustainability and capacity for enantiomerically pure product formation. Among various microbial processes, the fermentation of starch-based substrates stands out due to the abundance and renewability of raw materials like corn and potatoes.Hydrolysis of...
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Bioplastics01:27

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Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
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Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde
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Photocurable bioadhesive based on lactic acid.

D S Marques1, J M C Santos1, P Ferreira1

  • 1CIEPQPF, Department of Chemical Engineering, University of Coimbra, P-3030 790 Coimbra, Portugal.

Materials Science & Engineering. C, Materials for Biological Applications
|October 20, 2015
PubMed
Summary
This summary is machine-generated.

Novel biodegradable photocurable oligomers derived from lactic acid demonstrate promising bioadhesive properties. These materials show potential for biomedical applications due to their biocompatibility, antimicrobial activity, and hemostatic capabilities.

Keywords:
Bioadhesive formulationBiocompatibilityPhotocurablePolycondensationTelechelic lactic acid prepolymers

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Medical Device Technology

Background:

  • Bioadhesives are crucial for medical applications, requiring biocompatibility and biodegradability.
  • Photocurable materials offer controlled application and curing in biomedical settings.
  • Lactic acid-based polymers are known for their biocompatibility and biodegradability.

Purpose of the Study:

  • To synthesize and characterize novel photocurable, low molecular weight oligomers from lactic acid for bioadhesive applications.
  • To evaluate the biodegradability, adhesion performance, biocompatibility, and antimicrobial properties of the synthesized oligomers.
  • To assess the hemostatic potential of the cured material.

Main Methods:

  • Synthesis of telechelic lactic acid oligomers with OH end groups via self-esterification.
  • Methacrylic end-functionalization of oligomers using methacrylic anhydride.
  • Photocuring with Irgacure® 2959.
  • In vitro hydrolytic degradation studies in PBS.
  • Adhesion testing using pull-to-break tests on gelatin substrates.
  • Surface energy measurement via contact angles.
  • Cytotoxicity assessment using human fibroblasts.
  • Antimicrobial activity testing against Staphylococcus aureus and Escherichia coli.
  • Thrombogenicity assessment in contact with blood.

Main Results:

  • Successfully synthesized photocurable lactic acid-based oligomers.
  • Demonstrated in vitro biodegradability and good adhesion to aminated substrates.
  • Exhibited low surface energy, comparable to skin and blood.
  • Showed no cytotoxicity to human fibroblasts.
  • Displayed significant antimicrobial activity against tested bacteria.
  • Exhibited strong thrombogenic character, indicating hemostatic potential.

Conclusions:

  • The novel lactic acid-based photocurable oligomers are biodegradable, biocompatible, and possess desirable adhesive and antimicrobial properties.
  • The material's hemostatic character suggests utility in bleeding control.
  • These oligomers show significant potential for bioadhesive and other biomedical applications requiring photocurable, biodegradable, and biocompatible materials.