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Photochemically modified diamond-like carbon surfaces for neural interfaces.

A P Hopper1, J M Dugan1, A A Gill1

  • 1Department of Materials Science and Engineering, Kroto Research Institute, The University of Sheffield, Broad Lane, Sheffield S3 7HQ, UK.

Materials Science & Engineering. C, Materials for Biological Applications
|October 20, 2015
PubMed
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UV functionalization of diamond-like carbon (DLC) enhanced neuron and Schwann cell adhesion and growth. This biomaterial modification shows promise for neural interface devices.

Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Neuroscience

Background:

  • Diamond-like carbon (DLC) possesses desirable biomaterial properties.
  • Existing DLC surfaces may require modification for optimal biological integration.
  • Neural interface devices require biocompatible and cell-adhesive materials.

Purpose of the Study:

  • To modify DLC surfaces using UV functionalization to introduce amine and aldehyde groups.
  • To evaluate the impact of functionalized DLC on neuronal and Schwann cell adhesion, viability, and growth.
  • To assess the potential of functionalized DLC for neural interface applications.

Main Methods:

  • Diamond-like carbon (DLC) surfaces were modified via UV functionalization.
  • Amine and aldehyde functional groups were introduced onto the DLC surface.
Keywords:
AldehydeAmineDiamond-like carbonNeuronsSchwann cells

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  • Neuronal and primary rat Schwann cell cultures were used to assess cell adhesion, viability, and neurite outgrowth.

    • Main Results:

    • UV functionalization increased DLC surface hydrophilicity.
    • Amine and aldehyde functionalized DLC significantly enhanced neuron viability and adhesion.
    • Neurite outgrowth on functionalized DLC was comparable to poly-L-lysine coated controls.
    • Both functionalized surfaces supported Schwann cell adhesion and growth.

    Conclusions:

    • UV-induced surface functionalization of DLC is an effective method to enhance its biocompatibility.
    • Functionalized DLC surfaces promote neural cell adhesion, growth, and outgrowth.
    • This approach holds potential for developing advanced implantable neural interface devices.