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Updated: Mar 31, 2026

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
Published on: June 15, 2016
Targeting transcription factor STAT3 for cancer prevention and therapy
Edna Zhi Pei Chai1, Muthu K Shanmugam1, Frank Arfuso2
1Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Abstract:
Signal Transducers and Activators of Transcription (STATs) comprise an important class of transcription factors that have been implicated in a wide variety of essential cellular functions related to proliferation, survival, and angiogenesis. Among various STAT members, STAT3 is frequently overexpressed in tumor cells as well as tissue samples, and regulates the expression of numerous oncogenic genes controlling the growth and metastasis of tumor cells. The current review briefly discusses the importance of STAT3 as a potential target for cancer therapy and also provides novel insights into various classes of existing pharmacological inhibitors of this transcription factor that can be potentially developed as anti-cancer drugs.
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11:19Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts
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