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Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
Published on: December 15, 2023
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Hepatitis B virus infection in Indonesia
Yoshihiko Yano1, Takako Utsumi1, Maria Inge Lusida1
1Yoshihiko Yano, Takako Utsumi, Yoshitake Hayashi, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
World Journal of Gastroenterology
|October 20, 2015
Summary
Hepatitis B virus (HBV) infection is a major health concern in Indonesia, with diverse subgenotypes identified. Further research is needed to understand genotype-specific disease progression and treatment responses.
Area of Science:
- Hepatology
- Virology
- Epidemiology
Background:
- Chronic hepatitis B virus (HBV) infection affects 240 million globally, causing significant mortality from liver disease and hepatocellular carcinoma (HCC).
- Indonesia exhibits intermediate to high hepatitis B surface antigen endemicity, with specific high-risk populations including hemodialysis patients, men who have sex with men, and healthcare workers.
- Occult HBV infections are prevalent across various Indonesian demographics, including blood donors, hemodialysis patients, HIV-infected individuals, and children.
Purpose of the Study:
- To provide an overview of the epidemiology and clinical characteristics of HBV infection in Indonesia.
- To highlight the prevalence of different HBV subgenotypes in Indonesia, such as B3 and C1, and the identification of novel subgenotypes.
- To emphasize the need for further investigation into genotype-related pathogenicity, disease prognosis, and treatment effects, particularly concerning lamivudine resistance.
Main Methods:
- Review of existing epidemiological and clinical data on HBV infection in Indonesia.
- Identification and characterization of HBV subgenotypes circulating within Indonesia.
- Analysis of previously reported associations between HBV mutations, hepatic steatosis, and disease progression.
Main Results:
- The most common HBV subgenotypes in Indonesia are B3 and C1, with novel subgenotypes (C6-C16, D6) also identified.
- Hepatic steatosis is linked to disease progression in HBV-infected Indonesian patients.
- Specific mutations (Pre-S2, C1638T, T1753V) in HBV/B3 are associated with advanced liver disease, including HCC.
Conclusions:
- Indonesia harbors a diverse range of HBV subgenotypes, necessitating further research into their clinical implications.
- Understanding genotype-related pathogenicity and drug resistance, especially to lamivudine, is crucial for effective HBV management in Indonesia.
- Limited databases underscore the need for comprehensive data collection to improve the understanding and control of HBV infection in Indonesia.
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