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Pituitary Glioblastoma: A Case Report
Kazem Anvari1, Fariborz Samini2, Mohammad Faraji3
1Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran.
Iranian Journal of Cancer Prevention
|October 20, 2015
Summary
Malignant glioma, a rare sellaturcica tumor, can be overlooked. This case highlights the importance of considering glioblastoma in pituitary tumor diagnoses, even with atypical presentations.
Area of Science:
- Neuro-oncology
- Endocrinology
- Radiology
Background:
- Pituitary adenomas are common sellaturcica tumors.
- Unusual pituitary tumors, such as malignant glioma, may be missed by clinicians and radiologists.
- Malignant glioma is a rare but critical differential diagnosis for sellaturcica masses.
Observation:
- A 62-year-old male presented with sudden headache, nausea, vomiting, and vision changes.
- Skull radiography revealed sellaturcica expansion with a distinct lesion.
- MRI showed a heterogeneous, contrast-enhancing mass compressing the optic chiasm.
Findings:
- The tumor extended into the suprasellar region and optic chiasmatic area.
- Partial tumor resection was performed via a transsphenoidal approach.
- Pathological diagnosis confirmed glioblastoma through immunohistochemistry.
Implications:
- This case underscores the need for vigilance in diagnosing rare pituitary tumors.
- Radiologists and clinicians should consider malignant glioma in the differential diagnosis of sellaturcica lesions.
- Early and accurate diagnosis of malignant glioma is crucial for appropriate patient management.

