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Published on: January 18, 2017
Dimethyl fumarate inhibits integrin α4 expression in multiple sclerosis models
Yasuyuki Kihara1, Aran Groves1, Richard R Rivera1
1Department of Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute 10550 N. Torrey Pines Rd., DNC-118, La Jolla, California, 92037.
Abstract:
Dimethyl fumarate is an orally bioavailable compound for the treatment of multiple sclerosis and psoriasis. A mechanism involving nuclear factor erythroid 2-like 2 activation has been proposed to account for its efficacy in multiple sclerosis. Here, we report that dimethyl fumarate inhibits expression of integrin α4 on circulating lymphocytes in experimental autoimmune encephalomyelitis mice and also on activated human Jurkat T cells in a manner distinct from nuclear factor erythroid 2-like 2 activation. Our results offer an alternative mechanism for the efficacy of dimethyl fumarate in multiple sclerosis.
