Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

765
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
765
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

718
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
718
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

808
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
808
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

641
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
641
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

816
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
816
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

4.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cost Comparison: Evaluating Transfemoral and Transradial Access for Diagnostic Cerebral Angiography.

Stroke (Hoboken, N.J.)·2026
Same author

Perioperative Practices in Moyamoya Syndrome Revascularization: An International Transdisciplinary Survey.

Stroke (Hoboken, N.J.)·2026
Same author

Stereotactic radiosurgery versus observation for intracranial low-grade dural arteriovenous fistulas.

Journal of neurology, neurosurgery, and psychiatry·2025
Same author

Subarachnoid hemorrhage-associated brain injury and neurobehavioral deficits are reversed with synthetic adropin treatment through sustained Ser1179 phosphorylation of endothelial nitric oxide synthase.

Frontiers in stroke·2024
Same author

An Interdisciplinary Protocol for Ventriculoperitoneal Shunt Patient Selection in Normal Pressure Hydrocephalus.

World neurosurgery·2024
Same author

The International Association for the Study of Lung Cancer Lung Cancer Staging Project: Proposals for Revision of the Classification of Residual Tumor After Resection for the Forthcoming (Ninth) Edition of the TNM Classification of Lung Cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer·2024
Same journal

Remote Patient Monitoring to Improve Outcomes in Heart Failure.

Journal of cardiology & clinical research·2023
Same journal

Utility of Transthoracic Echocardiography and Carotid Doppler Ultrasound in Differential Diagnosis and Management of Ischemic Stroke in a Developing Country.

Journal of cardiology & clinical research·2014
Same journal

Xin Scaffolding Proteins and Arrhythmias.

Journal of cardiology & clinical research·2014
See all related articles

Related Experiment Video

Updated: Mar 31, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.4K

Alcoholic Cardiomyopathy: Multigenic Changes Underlie Cardiovascular Dysfunction.

Dimitri Laurent1, John G Edwards1

  • 1Department of Physiology, New York Medical College, USA.

Journal of Cardiology & Clinical Research
|October 20, 2015
PubMed
Summary
This summary is machine-generated.

Alcoholism causes significant health problems, including cardiovascular disease and dementia. Genetic factors influence individual susceptibility to alcohol

Keywords:
Alcoholic cardiomyopathyAlcoholismHeart failure

More Related Videos

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish
08:09

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

Published on: June 7, 2018

10.5K
Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model
05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

729

Related Experiment Videos

Last Updated: Mar 31, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.4K
A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish
08:09

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

Published on: June 7, 2018

10.5K
Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model
05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

729

Area of Science:

  • Cardiology
  • Toxicology
  • Genetics

Background:

  • Alcoholism is a leading cause of preventable death, linked to diverse health issues like cardiomyopathies, dementia, organ failure, and cancers.
  • While average alcohol consumption may show a J-shaped mortality curve, heavy or irregular drinking poses substantial cardiovascular risks.
  • Alcohol-induced cardiovascular disease has a complex, multigenic basis, with varied initial presentations such as diastolic dysfunction.

Purpose of the Study:

  • To explore the cellular and molecular mechanisms underlying alcohol-induced cardiovascular disease.
  • To investigate the role of genetic variations in individual responses to chronic alcohol consumption.
  • To identify genotypes that confer increased susceptibility to the detrimental effects of alcohol on the heart.

Main Methods:

  • Analysis of toxic metabolites (acetaldehyde, ROS) generated by ethanol exposure.
  • Examination of cellular signaling pathways altered by ethanol.
  • Microscopic and molecular investigation of cardiac tissue from individuals with alcoholic cardiomyopathy.

Main Results:

  • Ethanol metabolism produces toxic byproducts that disrupt cellular function and signaling pathways.
  • Alcoholic cardiomyopathy involves structural abnormalities in mitochondria and myofibrils, affecting contractility and metabolism.
  • Observed variations in disease presentation and severity suggest a genetic component influencing alcohol's cardiac impact.

Conclusions:

  • Chronic alcohol consumption directly damages myocardial cells, leading to impaired cardiac function and potentially sudden death.
  • Individual genetic makeup plays a crucial role in determining susceptibility and response to alcohol-related heart disease.
  • Further research into genotype-specific effects is essential for personalized prevention and treatment strategies for alcoholic cardiomyopathy.