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Sex Differences in Physiological Acclimatization after Transfer in Wistar Rats.

Johanna W M Arts1,2, Klaas Kramer3,4, Saskia S Arndt5

  • 1Department of Animals in Science & Society, Division of Animal Welfare & Laboratory Animal Science, Veterinary Faculty, Utrecht University, Utrecht, 3584 CM, The Netherlands. j.arts@uu.nl.

Animals : an Open Access Journal From MDPI
|October 20, 2015
PubMed
Summary

Animal transfer significantly impacts research outcomes. Acclimatization periods must consider sex-specific physiological and behavioral responses in Wistar rats to ensure reliable experimental data.

Keywords:
acclimatizationblood pressurecorticosteroneheart ratelocomotor activityrattransfertransportation

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Area of Science:

  • Laboratory animal science
  • Animal welfare
  • Research methodology

Background:

  • Laboratory animals are typically vendor-bred and transferred to research facilities.
  • Transfer procedures can introduce unintended variables affecting research results.
  • Understanding the impact of animal transfer is crucial for data integrity.

Purpose of the Study:

  • To compare physiological and behavioral parameters in Wistar rats before and after external and internal transfers.
  • To investigate the effects of transfer on body weight, plasma corticosterone, heart rate, blood pressure, and locomotor activity.
  • To account for sex differences in stress responsivity during transfer acclimatization.

Main Methods:

  • Wistar rats (male and female) were monitored for physiological and behavioral changes.
  • Parameters assessed included body weight, plasma corticosterone, heart rate, blood pressure, and locomotor activity.
  • Comparisons were made between transferred and non-transferred animals, and between sexes and light phases.

Main Results:

  • External transfer decreased body weight and increased plasma corticosterone and activity.
  • Heart rate responses to transfer differed between sexes: increased in females, decreased in males.
  • Physiological and behavioral parameters varied significantly between sexes and light phases, indicating sex-specific acclimatization.

Conclusions:

  • Acclimatization following animal transfer is sex-specific.
  • Researchers must consider sex differences when determining appropriate acclimatization periods.
  • Recommended acclimatization: at least 8 days for males and 2 weeks for females post-external transfer, with internal transfer 2 days prior to experiments.