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Related Experiment Videos

Bone marrow autotransplantation for solid tumors--prospects.

E Frei1, K Antman, B Teicher

  • 1Department of Medicine, Dana-Farber Cancer Institute, Boston, MA 02115.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|April 1, 1989
PubMed
Summary

Autologous bone marrow transplantation shows promise for metastatic solid tumors, especially breast cancer, by using intensive alkylating agent therapy. While effective, this approach has significant toxicity and cost concerns.

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Area of Science:

  • Oncology
  • Hematology
  • Cancer Therapeutics

Background:

  • Autologous bone marrow transplantation (AuBMT) is established for leukemias and lymphomas.
  • Solid tumors, particularly metastatic breast cancer, are being investigated for AuBMT.
  • Curative chemotherapy for solid tumors often requires dose maintenance, which is challenging.

Purpose of the Study:

  • To review the potential of AuBMT combined with intensive alkylating agent therapy for metastatic solid tumors.
  • To evaluate the preclinical and clinical evidence supporting this therapeutic approach.

Main Methods:

  • Review of preclinical studies on alkylating agents' effectiveness and synergy.
  • Analysis of cytokinetic data for combined intensive alkylating agent therapy.

Related Experiment Videos

  • Examination of clinical trial results for AuBMT in refractory breast cancer.

    • Main Results:

    • Alkylating agents demonstrate efficacy, reduced resistance, and synergy, supporting dose intensification.
    • Clinical trials show high response rates and substantial complete remission rates in breast cancer.
    • Responses have been short-lived, and the approach involves significant toxicity and cost.

    Conclusions:

    • Intensification regimens with combined alkylating agents in AuBMT show therapeutic potential for metastatic solid tumors.
    • Further research is warranted despite observed toxicity and cost.
    • This approach represents a promising area for cancer therapeutic research.