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Related Experiment Videos

CSF production in acute ventriculitis.

R E Breeze1, J G McComb, S Hyman

  • 1Department of Neurosurgery, University of Southern California School of Medicine, Los Angeles.

Journal of Neurosurgery
|April 1, 1989
PubMed
Summary

Acute ventriculitis significantly reduces cerebrospinal fluid (CSF) production. Experimental Escherichia coli infection in rabbits confirmed this, showing a 50-66% decrease in CSF formation due to choroid plexus inflammation.

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Area of Science:

  • Neuroscience
  • Pathology
  • Infectious Disease

Background:

  • Clinical observations suggest reduced cerebrospinal fluid (CSF) formation during acute ventriculitis.
  • Experimental validation of this phenomenon is limited.
  • Ventriculitis, an inflammation of the brain's ventricles, can have severe neurological consequences.

Purpose of the Study:

  • To experimentally investigate the effect of acute ventriculitis on CSF formation.
  • To elucidate the pathological changes in the choroid plexus during ventriculitis.
  • To confirm clinical observations regarding diminished CSF production.

Main Methods:

  • Induction of acute ventriculitis in New Zealand White rabbits via Escherichia coli injection into lateral ventricles.
  • Measurement of CSF formation using carbon-14-dextran perfusion in surviving rabbits 18 hours post-infection.

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  • Histological examination of brain tissue, focusing on the choroid plexus, meninges, and ependyma.

    • Main Results:

    • CSF formation was reduced by 50-66% in rabbits with experimental ventriculitis compared to normal rates.
    • Histopathology revealed extensive inflammatory infiltrate in the choroid plexus stroma.
    • Epithelial changes in the choroid plexus included cellular swelling and necrosis; meningitis, ependymitis, and encephalitis were also observed, but vasculitis was absent.

    Conclusions:

    • Acute ventriculitis causes a significant reduction in CSF formation, supporting clinical findings.
    • Inflammatory processes and cellular damage within the choroid plexus are likely responsible for the diminished CSF production.
    • Reduced choroidal blood flow and/or enterotoxins may contribute to the observed pathological alterations.