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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
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Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
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Epigenome-modifying tools in asthma.

Peter O Brook1, Mark M Perry1, Ian M Adcock1

  • 1Imperial College London, National Heart & Lung Institute, Dovehouse Street, London, SW3 6LY, UK.

Epigenomics
|October 20, 2015
PubMed
Summary
This summary is machine-generated.

Epigenetic modifications, which alter gene expression without changing DNA sequence, are linked to asthma development and severity. These epigenetic changes offer potential new therapeutic targets for this chronic respiratory disease.

Keywords:
DNA methylationT cellasthmaepigeneticshistone modificationmiRNAtherapeutics

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Area of Science:

  • Pulmonary Medicine
  • Genetics
  • Epigenetics

Background:

  • Asthma is a prevalent chronic respiratory disease affecting 300 million globally, causing 250,000 annual deaths.
  • The epigenome, encompassing DNA methylation, histone modifications, and noncoding RNA expression, influences gene function without altering DNA sequence.

Purpose of the Study:

  • To investigate the role of epigenetic alterations in asthma pathogenesis.
  • To explore the link between epigenetic modifications, asthma susceptibility, and disease severity.

Main Methods:

  • Review of existing literature on epigenetic mechanisms in asthma.
  • Analysis of studies reporting epigenetic changes in asthma patients and animal models.

Main Results:

  • Epigenetic alterations, including DNA methylation and histone modifications, are observed in asthma patients.
  • These epigenetic differences correlate with asthma severity and susceptibility.
  • Animal models indicate that epigenetic processes are integral to asthma development.

Conclusions:

  • Epigenetic modifications play a significant role in asthma.
  • Epigenetic mechanisms represent potential therapeutic targets for asthma intervention.