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Accuracy of the HVAD Pump Flow Estimation Algorithm.

Carlos Reyes¹, Neil Voskoboynikov, Katherine Chorpenning

¹From HeartWare, Inc., Miami Lakes, Florida.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)

|October 20, 2015

Summary

This summary is machine-generated.

The HeartWare continuous-flow ventricular assist device flow estimation algorithm accurately measures pump performance. This algorithm, using speed, current, and hematocrit, shows strong agreement with direct flow measurements in both in vitro and in vivo studies.

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Area of Science:

Biomedical Engineering
Cardiovascular Devices
Medical Device Technology

Background:

Controller algorithms are crucial for evaluating ventricular assist device (VAD) performance.
Accurate flow estimation is essential for optimizing VAD function and patient outcomes.
The HeartWare continuous-flow VAD utilizes a specific algorithm for flow estimation.

Purpose of the Study:

To assess the accuracy of the HeartWare VAD's flow estimation algorithm.
To validate the algorithm's performance across various conditions using in vitro and in vivo studies.

Main Methods:

In vitro testing involved three pumps in solutions mimicking hematocrits of 20-50% at 37°C.
In vivo studies utilized an ovine model (n=9) with a reference flow probe, adjusting pump speed from 1,800 to 4,000 rpm.
Linear regression analysis was employed to compare estimated and measured flow, alongside waveform fidelity assessment.

Main Results:

In vitro studies showed a correlation coefficient (r) > 0.94 between measured and estimated flow.
In vivo studies yielded a best-fit linear regression equation (y = 0.96x + 0.54) with r = 0.92.
High waveform fidelity (r > 0.96) was observed in non-suction cases with pulsatility > 2 L/min.

Conclusions:

The flow estimation algorithm demonstrates strong agreement with measured pump flow.
The algorithm is reliable for assessing both average flow magnitude and waveform fidelity in continuous-flow VADs.
This validated algorithm enhances the performance assessment capabilities of the HeartWare VAD system.