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Related Experiment Videos

Workup for male infertility.

L Grunfeld1

  • 1Department of Obstetrics and Gynecology, Mount Sinai Medical Center, New York, New York 10029.

The Journal of Reproductive Medicine
|February 1, 1989
PubMed
Summary
This summary is machine-generated.

Male infertility requires thorough evaluation beyond standard semen analysis. Even normal results may hide issues like infections or sperm defects, necessitating further testing for accurate diagnosis and treatment.

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Area of Science:

  • Reproductive Medicine
  • Andrology
  • Urology

Background:

  • Male infertility affects a significant portion of couples seeking fertility treatment.
  • Standard semen analysis is the primary diagnostic tool but has limitations.
  • Classifying infertile men based on hormonal profiles (hypogonadotropic, hypergonadotropic, normal gonadotropic) aids in diagnosis.

Purpose of the Study:

  • To emphasize the necessity of a comprehensive male infertility evaluation.
  • To highlight that normal semen analysis does not exclude male infertility.
  • To discuss additional diagnostic methods for identifying subtle causes of male infertility.

Main Methods:

  • Review of diagnostic approaches for male infertility.
  • Classification of infertile males based on hormonal status.

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  • Consideration of factors beyond basic semen parameters, including infections and sperm antibodies.
  • Utilizing specialized tests like the hamster oocyte penetration assay for sperm head defects.

    • Main Results:

    • Normal semen analysis results can still be associated with male infertility.
    • Infections and sperm antibodies can impair sperm function and fertilizing capacity.
    • Biochemical abnormalities can lead to sperm head defects detectable by specific assays.
    • Re-evaluation is crucial when initial assessments are normal but pregnancy is not achieved.

    Conclusions:

    • A thorough evaluation of the male partner is essential in all infertility cases.
    • Advanced diagnostic techniques are necessary when standard semen analysis is normal.
    • Repeat evaluations are recommended if no cause is found or if initial treatments fail.